P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
226 E 18 1 19 0.081 0.582 View mutations
227 S 19 0 19 0.000 0.442 View mutations
228 I 9 10 19 0.559 0.505 View mutations
229 S 9 10 19 0.501 0.450 View mutations
230 G 19 0 19 0.020 0.501 View mutations
231 F 10 9 19 0.473 0.495 View mutations
232 A 5 14 19 0.743 0.505 View mutations
233 H 10 9 19 0.501 0.482 View mutations
234 S 5 14 19 0.731 0.424 View mutations
235 C 19 0 19 0.024 0.561 View mutations
236 F 19 0 19 0.007 0.533 View mutations
237 Q 11 8 19 0.341 0.527 View mutations
238 Y 8 11 19 0.540 0.430 View mutations
239 A 2 17 19 0.896 0.391 View mutations
240 I 18 1 19 0.038 0.547 View mutations
241 Q 19 0 19 0.003 0.743 View mutations
242 K 13 6 19 0.303 0.552 View mutations
243 K 19 0 19 0.023 0.663 View mutations
244 W 19 0 19 0.003 0.595 View mutations
245 P 11 8 19 0.477 0.417 View mutations
246 L 3 16 19 0.782 0.457 View mutations
247 Y 19 0 19 0.054 0.498 View mutations
248 M 2 17 19 0.909 0.554 View mutations
249 S 0 19 19 1.000 0.651 View mutations
250 T 0 19 19 0.988 0.741 View mutations