P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
176 G 4 15 19 0.784 0.646 View mutations
177 D 0 19 19 1.000 0.723 View mutations
178 Q 5 14 19 0.764 0.585 View mutations
179 Y 1 18 19 0.946 0.562 View mutations
180 K 15 4 19 0.244 0.452 View mutations
181 A 18 1 19 0.037 0.476 View mutations
182 T 19 0 19 0.001 0.353 View mutations
183 D 19 0 19 0.033 0.436 View mutations
184 F 19 0 19 0.013 0.602 View mutations
185 V 19 0 19 0.000 0.688 View mutations
186 A 19 0 19 0.008 0.578 View mutations
187 D 19 0 19 0.003 0.650 View mutations
188 R 19 0 19 0.006 0.737 View mutations
189 A 19 0 19 0.036 0.693 View mutations
190 G 18 1 19 0.051 0.447 View mutations
191 T 19 0 19 0.005 0.789 View mutations
192 F 12 7 19 0.388 0.454 View mutations
193 K 17 2 19 0.121 0.802 View mutations
194 M 6 13 19 0.694 0.416 View mutations
195 V 19 0 19 0.012 0.857 View mutations
196 F 10 9 19 0.477 0.454 View mutations
197 T 19 0 19 0.005 0.853 View mutations
198 P 19 0 19 0.002 0.775 View mutations
199 K 19 0 19 0.006 0.836 View mutations
200 D 18 1 19 0.068 0.847 View mutations