P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
251 K 0 19 19 1.000 0.779 View mutations
252 N 1 18 19 0.957 0.727 View mutations
253 T 0 19 19 1.000 0.773 View mutations
254 I 6 13 19 0.671 0.584 View mutations
255 L 12 7 19 0.377 0.444 View mutations
256 K 0 19 19 0.981 0.640 View mutations
257 A 6 13 19 0.671 0.430 View mutations
258 Y 0 19 19 0.997 0.675 View mutations
259 D 1 18 19 0.935 0.695 View mutations
260 G 19 0 19 0.001 0.325 View mutations
261 R 11 8 19 0.459 0.435 View mutations
262 F 0 19 19 1.000 0.619 View mutations
263 K 9 10 19 0.537 0.503 View mutations
264 D 18 1 19 0.086 0.392 View mutations
265 I 12 7 19 0.404 0.481 View mutations
266 F 15 4 19 0.325 0.448 View mutations
267 Q 9 10 19 0.517 0.437 View mutations
268 E 15 4 19 0.249 0.599 View mutations
269 I 16 3 19 0.198 0.597 View mutations
270 F 9 10 19 0.537 0.430 View mutations
271 D 5 14 19 0.700 0.372 View mutations
272 K 19 0 19 0.022 0.841 View mutations
273 H 18 1 19 0.053 0.742 View mutations
274 Y 1 18 19 0.928 0.301 View mutations
275 K 18 1 19 0.085 0.680 View mutations