P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
201 G 19 0 19 0.005 0.813 View mutations
202 S 19 0 19 0.007 0.956 View mutations
203 G 19 0 19 0.019 0.911 View mutations
204 V 19 0 19 0.036 0.943 View mutations
205 K 17 2 19 0.153 0.726 View mutations
206 E 17 2 19 0.115 0.849 View mutations
207 W 10 9 19 0.449 0.495 View mutations
208 E 19 0 19 0.015 0.901 View mutations
209 V 17 2 19 0.156 0.563 View mutations
210 Y 19 0 19 0.004 0.610 View mutations
211 N 19 0 19 0.007 0.778 View mutations
212 F 1 18 19 0.916 0.306 View mutations
213 P 19 0 19 0.018 0.742 View mutations
214 A 19 0 19 0.008 0.687 View mutations
215 G 19 0 19 0.046 0.599 View mutations
216 G 0 19 19 0.998 0.474 View mutations
217 V 9 10 19 0.496 0.435 View mutations
218 G 8 11 19 0.617 0.432 View mutations
219 M 18 1 19 0.140 0.494 View mutations
220 G 19 0 19 0.003 0.460 View mutations
221 M 15 4 19 0.265 0.476 View mutations
222 Y 15 4 19 0.256 0.397 View mutations
223 N 19 0 19 0.015 0.360 View mutations
224 T 14 5 19 0.245 0.444 View mutations
225 D 18 1 19 0.102 0.539 View mutations