P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
276 T 15 4 19 0.259 0.659 View mutations
277 D 18 1 19 0.060 0.806 View mutations
278 F 19 0 19 0.026 0.471 View mutations
279 D 17 2 19 0.118 0.689 View mutations
280 K 13 6 19 0.344 0.596 View mutations
281 N 16 3 19 0.169 0.626 View mutations
282 K 13 6 19 0.291 0.500 View mutations
283 I 14 5 19 0.274 0.412 View mutations
284 W 2 17 19 0.893 0.392 View mutations
285 Y 0 19 19 0.975 0.660 View mutations
286 E 17 2 19 0.125 0.388 View mutations
287 H 6 13 19 0.675 0.584 View mutations
288 R 0 19 19 0.992 0.755 View mutations
289 L 0 19 19 0.956 0.814 View mutations
290 I 0 19 19 1.000 0.783 View mutations
291 D 0 19 19 1.000 0.735 View mutations
292 D 0 19 19 1.000 0.704 View mutations
293 M 12 7 19 0.380 0.488 View mutations
294 V 0 19 19 1.000 0.563 View mutations
295 A 17 2 19 0.137 0.404 View mutations
296 Q 18 1 19 0.041 0.530 View mutations
297 V 10 9 19 0.472 0.449 View mutations
298 L 7 12 19 0.586 0.443 View mutations
299 K 2 17 19 0.893 0.452 View mutations
300 S 2 17 19 0.842 0.439 View mutations