P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
301 S 19 0 19 0.026 0.537 View mutations
302 G 19 0 19 0.006 0.384 View mutations
303 G 2 17 19 0.903 0.508 View mutations
304 F 1 18 19 0.935 0.550 View mutations
305 V 18 1 19 0.055 0.404 View mutations
306 W 0 19 19 0.986 0.690 View mutations
307 A 7 12 19 0.607 0.553 View mutations
308 C 8 11 19 0.572 0.533 View mutations
309 K 16 3 19 0.178 0.321 View mutations
310 N 3 16 19 0.819 0.758 View mutations
311 Y 0 19 19 1.000 0.918 View mutations
312 D 17 2 19 0.113 0.211 View mutations
313 G 12 7 19 0.381 0.385 View mutations
314 D 0 19 19 1.000 1.000 View mutations
315 V 0 19 19 1.000 0.791 View mutations
316 Q 10 9 19 0.473 0.492 View mutations
317 S 2 17 19 0.894 0.703 View mutations
318 D 16 3 19 0.207 0.322 View mutations
319 I 5 14 19 0.742 0.456 View mutations
320 L 11 8 19 0.470 0.468 View mutations
321 A 0 19 19 0.987 0.848 View mutations
322 Q 2 17 19 0.908 0.784 View mutations
323 G 3 16 19 0.839 0.702 View mutations
324 F 1 18 19 0.947 0.728 View mutations
325 G 0 19 19 1.000 0.964 View mutations