P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
326 S 0 19 19 1.000 0.813 View mutations
327 L 0 19 19 1.000 0.805 View mutations
328 G 0 19 19 1.000 0.775 View mutations
329 L 1 18 19 0.943 0.667 View mutations
330 M 0 19 19 0.995 0.698 View mutations
331 T 1 18 19 0.948 0.640 View mutations
332 S 0 19 19 1.000 0.697 View mutations
333 V 6 13 19 0.665 0.502 View mutations
334 L 0 19 19 1.000 0.660 View mutations
335 V 9 10 19 0.532 0.434 View mutations
336 C 11 8 19 0.372 0.434 View mutations
337 P 14 5 19 0.221 0.451 View mutations
338 D 19 0 19 0.001 0.534 View mutations
339 G 19 0 19 0.000 0.454 View mutations
340 K 16 3 19 0.164 0.609 View mutations
341 T 19 0 19 0.000 0.427 View mutations
342 I 10 9 19 0.466 0.438 View mutations
343 E 1 18 19 0.919 0.618 View mutations
344 A 1 18 19 0.952 0.615 View mutations
345 E 17 2 19 0.106 0.272 View mutations
346 A 4 15 19 0.793 0.703 View mutations
347 A 0 19 19 1.000 0.860 View mutations
348 H 0 19 19 1.000 0.897 View mutations
349 G 0 19 19 1.000 0.944 View mutations
350 T 0 19 19 1.000 0.879 View mutations