P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
126 F 2 17 19 0.904 0.613 View mutations
127 K 9 10 19 0.547 0.445 View mutations
128 L 0 19 19 1.000 0.686 View mutations
129 K 11 8 19 0.482 0.433 View mutations
130 K 4 15 19 0.802 0.401 View mutations
131 M 0 19 19 1.000 0.598 View mutations
132 W 1 18 19 0.948 0.607 View mutations
133 K 4 15 19 0.750 0.462 View mutations
134 S 1 18 19 0.963 0.726 View mutations
135 P 7 12 19 0.584 0.593 View mutations
136 N 0 19 19 0.992 0.790 View mutations
137 G 0 19 19 1.000 0.702 View mutations
138 T 0 19 19 0.998 0.743 View mutations
139 I 1 18 19 0.927 0.669 View mutations
140 R 0 19 19 1.000 0.648 View mutations
141 N 0 19 19 0.999 0.641 View mutations
142 I 11 8 19 0.429 0.494 View mutations
143 L 19 0 19 0.000 0.347 View mutations
144 G 7 12 19 0.594 0.521 View mutations
145 G 7 12 19 0.624 0.561 View mutations
146 T 19 0 19 0.013 0.423 View mutations
147 V 1 18 19 0.946 0.601 View mutations
148 F 19 0 19 0.000 0.353 View mutations
149 R 1 18 19 0.948 0.660 View mutations
150 E 19 0 19 0.005 0.467 View mutations