P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
151 P 12 7 19 0.414 0.496 View mutations
152 I 0 19 19 0.990 0.512 View mutations
153 I 19 0 19 0.050 0.449 View mutations
154 C 18 1 19 0.093 0.528 View mutations
155 K 17 2 19 0.170 0.636 View mutations
156 N 18 1 19 0.075 0.482 View mutations
157 I 8 11 19 0.594 0.506 View mutations
158 P 12 7 19 0.403 0.488 View mutations
159 R 19 0 19 0.057 0.459 View mutations
160 L 17 2 19 0.116 0.436 View mutations
161 V 4 15 19 0.809 0.520 View mutations
162 P 9 10 19 0.568 0.442 View mutations
163 G 11 8 19 0.343 0.463 View mutations
164 W 1 18 19 0.960 0.535 View mutations
165 T 19 0 19 0.056 0.553 View mutations
166 K 18 1 19 0.143 0.598 View mutations
167 P 19 0 19 0.002 0.438 View mutations
168 I 3 16 19 0.840 0.564 View mutations
169 T 18 1 19 0.125 0.377 View mutations
170 I 18 1 19 0.114 0.398 View mutations
171 G 3 16 19 0.816 0.602 View mutations
172 R 3 16 19 0.856 0.659 View mutations
173 H 8 11 19 0.568 0.527 View mutations
174 A 4 15 19 0.732 0.637 View mutations
175 H 2 17 19 0.830 0.584 View mutations