P51580 (TPMT)

Overview
Predicted structure (AF):
AF-P51580-F1-model_v4
Uniprot entry:
P51580
Gene:
TPMT
Protein length:
245 residues
Mutations found:
4654
Benign based on D2Deep prediction:
2752 out of 4654 mutations
Pathogenic based on D2Deep prediction:
1902 out of 4654 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4654 mutations across 245 unique positions. There are 2752 benign and 1902 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
101 T 19 0 19 0.004 0.361 View mutations
102 E 7 12 19 0.595 0.534 View mutations
103 Q 1 18 19 0.925 0.703 View mutations
104 N 1 18 19 0.952 0.612 View mutations
105 L 0 19 19 1.000 0.797 View mutations
106 S 10 9 19 0.495 0.496 View mutations
107 Y 6 13 19 0.642 0.575 View mutations
108 S 16 3 19 0.240 0.428 View mutations
109 E 19 0 19 0.009 0.387 View mutations
110 E 19 0 19 0.000 0.411 View mutations
111 P 18 1 19 0.061 0.438 View mutations
112 I 19 0 19 0.028 0.475 View mutations
113 T 19 0 19 0.000 0.492 View mutations
114 E 18 1 19 0.065 0.441 View mutations
115 I 12 7 19 0.358 0.490 View mutations
116 P 19 0 19 0.037 0.400 View mutations
117 G 16 3 19 0.271 0.432 View mutations
118 T 18 1 19 0.073 0.479 View mutations
119 K 2 17 19 0.907 0.477 View mutations
120 V 19 0 19 0.040 0.419 View mutations
121 F 1 18 19 0.900 0.599 View mutations
122 K 18 1 19 0.057 0.365 View mutations
123 S 0 19 19 0.988 0.559 View mutations
124 S 16 3 19 0.175 0.432 View mutations
125 S 8 11 19 0.521 0.436 View mutations