P51580 (TPMT)

Overview
Predicted structure (AF):
AF-P51580-F1-model_v4
Uniprot entry:
P51580
Gene:
TPMT
Protein length:
245 residues
Mutations found:
4654
Benign based on D2Deep prediction:
2752 out of 4654 mutations
Pathogenic based on D2Deep prediction:
1902 out of 4654 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4654 mutations across 245 unique positions. There are 2752 benign and 1902 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
126 G 0 19 19 0.904 0.581 View mutations
127 N 3 16 19 0.799 0.511 View mutations
128 I 0 19 19 0.992 0.653 View mutations
129 S 15 4 19 0.222 0.495 View mutations
130 L 0 19 19 1.000 0.673 View mutations
131 Y 1 18 19 0.941 0.578 View mutations
132 C 0 19 19 0.996 0.672 View mutations
133 C 1 18 19 0.939 0.628 View mutations
134 S 6 13 19 0.720 0.519 View mutations
135 I 13 6 19 0.344 0.452 View mutations
136 F 3 16 19 0.805 0.597 View mutations
137 D 4 15 19 0.693 0.539 View mutations
138 L 5 14 19 0.763 0.525 View mutations
139 P 9 10 19 0.560 0.435 View mutations
140 R 12 7 19 0.434 0.422 View mutations
141 T 19 0 19 0.006 0.542 View mutations
142 N 19 0 19 0.001 0.553 View mutations
143 I 19 0 19 0.001 0.373 View mutations
144 G 16 3 19 0.216 0.486 View mutations
145 K 19 0 19 0.023 0.483 View mutations
146 F 17 2 19 0.107 0.459 View mutations
147 D 10 9 19 0.480 0.496 View mutations
148 M 19 0 19 0.013 0.497 View mutations
149 I 19 0 19 0.050 0.343 View mutations
150 W 15 4 19 0.325 0.370 View mutations