P61073 (CXCR4)

Overview
Predicted structure (AF):
AF-P61073-F1-model_v4
Uniprot entry:
P61073
Gene:
CXCR4
Protein length:
352 residues
Mutations found:
6687
Benign based on D2Deep prediction:
2592 out of 6687 mutations
Pathogenic based on D2Deep prediction:
4095 out of 6687 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 6687 mutations across 352 unique positions. There are 2592 benign and 4095 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
226 L 0 19 19 0.989 0.647 View mutations
227 S 17 2 19 0.111 0.449 View mutations
228 H 8 11 19 0.576 0.433 View mutations
229 S 0 19 19 1.000 0.501 View mutations
230 K 0 19 19 0.989 0.445 View mutations
231 G 0 19 19 0.994 0.494 View mutations
232 H 9 10 19 0.583 0.435 View mutations
233 Q 0 19 19 1.000 0.547 View mutations
234 K 0 19 19 1.000 0.665 View mutations
235 R 5 14 19 0.748 0.568 View mutations
236 K 15 4 19 0.229 0.436 View mutations
237 A 0 19 19 1.000 0.760 View mutations
238 L 0 19 19 1.000 0.792 View mutations
239 K 0 19 19 1.000 0.697 View mutations
240 T 2 17 19 0.908 0.693 View mutations
241 T 0 19 19 0.999 0.749 View mutations
242 V 1 18 19 0.951 0.613 View mutations
243 I 2 17 19 0.886 0.538 View mutations
244 L 3 16 19 0.781 0.642 View mutations
245 I 1 18 19 0.926 0.656 View mutations
246 L 3 16 19 0.838 0.501 View mutations
247 A 7 12 19 0.608 0.517 View mutations
248 F 0 19 19 0.977 0.711 View mutations
249 F 0 19 19 1.000 0.615 View mutations
250 A 8 11 19 0.584 0.435 View mutations