P61073 (CXCR4)

Overview
Predicted structure (AF):
AF-P61073-F1-model_v4
Uniprot entry:
P61073
Gene:
CXCR4
Protein length:
352 residues
Mutations found:
6687
Benign based on D2Deep prediction:
2592 out of 6687 mutations
Pathogenic based on D2Deep prediction:
4095 out of 6687 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 6687 mutations across 352 unique positions. There are 2592 benign and 4095 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
201 F 8 11 19 0.538 0.434 View mutations
202 Q 17 2 19 0.147 0.392 View mutations
203 H 19 0 19 0.007 0.458 View mutations
204 I 19 0 19 0.067 0.421 View mutations
205 M 5 14 19 0.726 0.506 View mutations
206 V 0 19 19 0.977 0.631 View mutations
207 G 0 19 19 1.000 0.686 View mutations
208 L 1 18 19 0.972 0.660 View mutations
209 I 5 14 19 0.763 0.537 View mutations
210 L 17 2 19 0.097 0.402 View mutations
211 P 0 19 19 1.000 0.799 View mutations
212 G 0 19 19 1.000 0.688 View mutations
213 I 1 18 19 0.938 0.579 View mutations
214 V 1 18 19 0.948 0.662 View mutations
215 I 0 19 19 1.000 0.777 View mutations
216 L 0 19 19 1.000 0.676 View mutations
217 S 3 16 19 0.798 0.540 View mutations
218 C 0 19 19 0.988 0.678 View mutations
219 Y 0 19 19 0.966 0.802 View mutations
220 C 14 5 19 0.288 0.438 View mutations
221 I 19 0 19 0.011 0.438 View mutations
222 I 9 10 19 0.566 0.512 View mutations
223 I 17 2 19 0.126 0.363 View mutations
224 S 19 0 19 0.040 0.367 View mutations
225 K 13 6 19 0.372 0.492 View mutations