P61073 (CXCR4)

Overview
Predicted structure (AF):
AF-P61073-F1-model_v4
Uniprot entry:
P61073
Gene:
CXCR4
Protein length:
352 residues
Mutations found:
6687
Benign based on D2Deep prediction:
2592 out of 6687 mutations
Pathogenic based on D2Deep prediction:
4095 out of 6687 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 6687 mutations across 352 unique positions. There are 2592 benign and 4095 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
251 C 0 19 19 1.000 0.680 View mutations
252 W 0 19 19 1.000 0.597 View mutations
253 L 0 19 19 1.000 0.597 View mutations
254 P 0 19 19 0.999 0.564 View mutations
255 Y 0 19 19 0.977 0.606 View mutations
256 Y 1 18 19 0.919 0.457 View mutations
257 I 1 18 19 0.914 0.405 View mutations
258 G 0 19 19 0.977 0.499 View mutations
259 I 5 14 19 0.742 0.522 View mutations
260 S 17 2 19 0.110 0.442 View mutations
261 I 5 14 19 0.775 0.432 View mutations
262 D 0 19 19 0.988 0.495 View mutations
263 S 14 5 19 0.239 0.426 View mutations
264 F 8 11 19 0.547 0.434 View mutations
265 I 10 9 19 0.447 0.447 View mutations
266 L 16 3 19 0.184 0.493 View mutations
267 L 9 10 19 0.559 0.436 View mutations
268 E 7 12 19 0.572 0.417 View mutations
269 I 4 15 19 0.762 0.392 View mutations
270 I 3 16 19 0.773 0.389 View mutations
271 K 11 8 19 0.422 0.498 View mutations
272 Q 18 1 19 0.051 0.668 View mutations
273 G 13 6 19 0.311 0.524 View mutations
274 C 0 19 19 1.000 0.488 View mutations
275 E 18 1 19 0.056 0.620 View mutations