P61073 (CXCR4)

Overview
Predicted structure (AF):
AF-P61073-F1-model_v4
Uniprot entry:
P61073
Gene:
CXCR4
Protein length:
352 residues
Mutations found:
6687
Benign based on D2Deep prediction:
2592 out of 6687 mutations
Pathogenic based on D2Deep prediction:
4095 out of 6687 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 6687 mutations across 352 unique positions. There are 2592 benign and 4095 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
151 L 1 18 19 0.867 0.504 View mutations
152 A 1 18 19 0.959 0.514 View mutations
153 E 10 9 19 0.451 0.423 View mutations
154 K 6 13 19 0.687 0.435 View mutations
155 V 3 16 19 0.834 0.458 View mutations
156 V 5 14 19 0.686 0.547 View mutations
157 Y 1 18 19 0.898 0.558 View mutations
158 V 3 16 19 0.811 0.529 View mutations
159 G 0 19 19 0.990 0.592 View mutations
160 V 1 18 19 0.925 0.680 View mutations
161 W 0 19 19 1.000 0.612 View mutations
162 I 1 18 19 0.948 0.597 View mutations
163 P 0 19 19 1.000 0.622 View mutations
164 A 0 19 19 1.000 0.676 View mutations
165 L 11 8 19 0.334 0.433 View mutations
166 L 2 17 19 0.907 0.552 View mutations
167 L 6 13 19 0.720 0.562 View mutations
168 T 8 11 19 0.582 0.515 View mutations
169 I 14 5 19 0.279 0.486 View mutations
170 P 0 19 19 0.997 0.696 View mutations
171 D 0 19 19 1.000 0.651 View mutations
172 F 11 8 19 0.397 0.414 View mutations
173 I 18 1 19 0.045 0.384 View mutations
174 F 16 3 19 0.173 0.430 View mutations
175 A 16 3 19 0.193 0.467 View mutations