Q06643 (TNFC)

Overview
Predicted structure (AF):
AF-Q06643-F1-model_v4
Uniprot entry:
Q06643
Gene:
TNFC
Protein length:
244 residues
Mutations found:
4635
Benign based on D2Deep prediction:
3101 out of 4635 mutations
Pathogenic based on D2Deep prediction:
1534 out of 4635 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4635 mutations across 244 unique positions. There are 3101 benign and 1534 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
101 G 19 0 19 0.000 0.445 View mutations
102 L 19 0 19 0.008 0.469 View mutations
103 G 19 0 19 0.040 0.429 View mutations
104 W 19 0 19 0.110 0.352 View mutations
105 E 17 2 19 0.167 0.376 View mutations
106 T 18 1 19 0.061 0.366 View mutations
107 T 19 0 19 0.002 0.486 View mutations
108 K 18 1 19 0.037 0.500 View mutations
109 E 19 0 19 0.007 0.385 View mutations
110 Q 19 0 19 0.002 0.418 View mutations
111 A 19 0 19 0.012 0.338 View mutations
112 F 18 1 19 0.032 0.310 View mutations
113 L 19 0 19 0.035 0.347 View mutations
114 T 19 0 19 0.003 0.379 View mutations
115 S 15 4 19 0.266 0.465 View mutations
116 G 18 1 19 0.098 0.413 View mutations
117 T 17 2 19 0.192 0.368 View mutations
118 Q 17 2 19 0.115 0.502 View mutations
119 F 6 13 19 0.616 0.444 View mutations
120 S 15 4 19 0.196 0.540 View mutations
121 D 16 3 19 0.215 0.547 View mutations
122 A 14 5 19 0.299 0.468 View mutations
123 E 7 12 19 0.585 0.428 View mutations
124 G 0 19 19 0.963 0.453 View mutations
125 L 0 19 19 0.980 0.672 View mutations