Q06643 (TNFC)

Overview
Predicted structure (AF):
AF-Q06643-F1-model_v4
Uniprot entry:
Q06643
Gene:
TNFC
Protein length:
244 residues
Mutations found:
4635
Benign based on D2Deep prediction:
3101 out of 4635 mutations
Pathogenic based on D2Deep prediction:
1534 out of 4635 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4635 mutations across 244 unique positions. There are 3101 benign and 1534 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
126 A 3 16 19 0.716 0.474 View mutations
127 L 1 18 19 0.908 0.604 View mutations
128 P 1 18 19 0.903 0.707 View mutations
129 Q 7 12 19 0.637 0.529 View mutations
130 D 0 19 19 0.994 0.642 View mutations
131 G 1 18 19 0.914 0.711 View mutations
132 L 3 16 19 0.819 0.631 View mutations
133 Y 10 9 19 0.557 0.489 View mutations
134 Y 1 18 19 0.929 0.652 View mutations
135 L 8 11 19 0.518 0.534 View mutations
136 Y 0 19 19 0.992 0.679 View mutations
137 C 1 18 19 0.941 0.679 View mutations
138 L 6 13 19 0.624 0.515 View mutations
139 V 3 16 19 0.798 0.685 View mutations
140 G 2 17 19 0.877 0.714 View mutations
141 Y 6 13 19 0.656 0.595 View mutations
142 R 19 0 19 0.021 0.368 View mutations
143 G 19 0 19 0.012 0.290 View mutations
144 R 19 0 19 0.005 0.489 View mutations
145 A 19 0 19 0.000 0.492 View mutations
146 P 19 0 19 0.000 0.608 View mutations
147 P 18 1 19 0.055 0.672 View mutations
148 G 19 0 19 0.000 0.797 View mutations
149 G 19 0 19 0.000 0.823 View mutations
150 G 19 0 19 0.000 0.894 View mutations