O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
376 R 19 0 19 0.022 0.201 View mutations
377 M 15 4 19 0.240 0.381 View mutations
378 T 0 19 19 1.000 0.846 View mutations
379 R 9 10 19 0.515 0.519 View mutations
380 F 5 14 19 0.744 0.602 View mutations
381 F 19 0 19 0.095 0.336 View mutations
382 T 3 16 19 0.839 0.635 View mutations
383 K 8 11 19 0.584 0.511 View mutations
384 L 17 2 19 0.110 0.468 View mutations
385 D 19 0 19 0.012 0.462 View mutations
386 A 15 4 19 0.195 0.477 View mutations
387 D 16 3 19 0.141 0.492 View mutations
388 K 19 0 19 0.001 0.513 View mutations
389 S 5 14 19 0.756 0.538 View mutations
390 Y 18 1 19 0.063 0.372 View mutations
391 Q 19 0 19 0.006 0.536 View mutations
392 C 19 0 19 0.003 0.507 View mutations
393 L 6 13 19 0.672 0.568 View mutations
394 K 18 1 19 0.064 0.479 View mutations
395 E 19 0 19 0.000 0.397 View mutations
396 T 18 1 19 0.059 0.516 View mutations
397 C 5 14 19 0.683 0.533 View mutations
398 E 18 1 19 0.064 0.493 View mutations
399 K 19 0 19 0.001 0.420 View mutations
400 L 18 1 19 0.033 0.370 View mutations