O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
101 G 19 0 19 0.000 0.194 View mutations
102 M 15 4 19 0.218 0.365 View mutations
103 P 17 2 19 0.117 0.440 View mutations
104 E 5 14 19 0.764 0.520 View mutations
105 P 18 1 19 0.114 0.414 View mutations
106 D 18 1 19 0.048 0.486 View mutations
107 A 19 0 19 0.042 0.196 View mutations
108 Q 14 5 19 0.243 0.457 View mutations
109 R 19 0 19 0.000 0.419 View mutations
110 F 18 1 19 0.086 0.348 View mutations
111 F 0 19 19 0.965 0.726 View mutations
112 H 19 0 19 0.002 0.499 View mutations
113 Q 19 0 19 0.000 0.339 View mutations
114 L 9 10 19 0.459 0.510 View mutations
115 M 12 7 19 0.391 0.500 View mutations
116 A 19 0 19 0.031 0.352 View mutations
117 G 1 18 19 0.943 0.561 View mutations
118 V 17 2 19 0.190 0.349 View mutations
119 V 18 1 19 0.059 0.481 View mutations
120 Y 17 2 19 0.113 0.440 View mutations
121 L 5 14 19 0.726 0.524 View mutations
122 H 18 1 19 0.077 0.370 View mutations
123 G 18 1 19 0.131 0.470 View mutations
124 I 18 1 19 0.072 0.393 View mutations
125 G 0 19 19 0.910 0.651 View mutations