P10415 (BCL2)

Overview
Predicted structure (AF):
AF-P10415-F1-model_v4
Uniprot entry:
P10415
Gene:
BCL2
Protein length:
239 residues
Mutations found:
4540
Benign based on D2Deep prediction:
3113 out of 4540 mutations
Pathogenic based on D2Deep prediction:
1427 out of 4540 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4540 mutations across 239 unique positions. There are 3113 benign and 1427 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
176 W 19 0 19 0.004 0.171 View mutations
177 M 17 2 19 0.101 0.178 View mutations
178 T 19 0 19 0.009 0.161 View mutations
179 E 19 0 19 0.015 0.222 View mutations
180 Y 19 0 19 0.040 0.141 View mutations
181 L 19 0 19 0.002 0.086 View mutations
182 N 19 0 19 0.001 0.185 View mutations
183 R 19 0 19 0.010 0.363 View mutations
184 H 17 2 19 0.210 0.275 View mutations
185 L 19 0 19 0.008 0.193 View mutations
186 H 19 0 19 0.002 0.235 View mutations
187 T 18 1 19 0.104 0.400 View mutations
188 W 19 0 19 0.013 0.147 View mutations
189 I 7 12 19 0.639 0.621 View mutations
190 Q 15 4 19 0.231 0.393 View mutations
191 D 1 18 19 0.875 0.746 View mutations
192 N 15 4 19 0.235 0.287 View mutations
193 G 5 14 19 0.670 0.648 View mutations
194 G 0 19 19 0.983 0.716 View mutations
195 W 11 8 19 0.431 0.474 View mutations
196 D 19 0 19 0.036 0.449 View mutations
197 A 19 0 19 0.018 0.512 View mutations
198 F 8 11 19 0.560 0.433 View mutations
199 V 19 0 19 0.000 0.543 View mutations
200 E 9 10 19 0.508 0.445 View mutations