P15976 (GATA1)

Overview
Predicted structure (AF):
AF-P15976-F1-model_v4
Uniprot entry:
P15976
Gene:
GATA1
Protein length:
413 residues
Mutations found:
7846
Benign based on D2Deep prediction:
3634 out of 7846 mutations
Pathogenic based on D2Deep prediction:
4212 out of 7846 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 7846 mutations across 413 unique positions. There are 3634 benign and 4212 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
276 D 0 19 19 0.991 0.843 View mutations
277 P 0 19 19 1.000 0.908 View mutations
278 V 1 18 19 0.945 0.908 View mutations
279 C 0 19 19 1.000 0.826 View mutations
280 N 0 19 19 1.000 0.935 View mutations
281 A 0 19 19 1.000 0.909 View mutations
282 C 0 19 19 1.000 0.874 View mutations
283 G 0 19 19 1.000 0.886 View mutations
284 L 0 19 19 1.000 0.857 View mutations
285 Y 1 18 19 0.955 0.780 View mutations
286 Y 1 18 19 0.953 0.789 View mutations
287 K 0 19 19 1.000 0.793 View mutations
288 L 0 19 19 1.000 0.804 View mutations
289 H 5 14 19 0.747 0.651 View mutations
290 Q 0 19 19 0.995 0.705 View mutations
291 V 0 19 19 0.987 0.891 View mutations
292 N 7 12 19 0.672 0.590 View mutations
293 R 0 19 19 0.975 0.849 View mutations
294 P 0 19 19 0.999 0.950 View mutations
295 L 3 16 19 0.793 0.815 View mutations
296 T 3 16 19 0.722 0.800 View mutations
297 M 3 16 19 0.846 0.814 View mutations
298 R 6 13 19 0.681 0.633 View mutations
299 K 6 13 19 0.673 0.633 View mutations
300 D 11 8 19 0.436 0.421 View mutations