P31749 (AKT1)

Overview
Predicted structure (AF):
AF-P31749-F1-model_v4
Uniprot entry:
P31749
Gene:
AKT1
Protein length:
480 residues
Mutations found:
9119
Benign based on D2Deep prediction:
5131 out of 9119 mutations
Pathogenic based on D2Deep prediction:
3988 out of 9119 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 9119 mutations across 480 unique positions. There are 5131 benign and 3988 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
251 R 2 17 19 0.899 0.659 View mutations
252 F 1 18 19 0.945 0.811 View mutations
253 Y 0 19 19 1.000 0.989 View mutations
254 G 6 13 19 0.690 0.555 View mutations
255 A 2 17 19 0.865 0.704 View mutations
256 E 0 19 19 0.993 0.897 View mutations
257 I 0 19 19 1.000 0.785 View mutations
258 V 8 11 19 0.569 0.506 View mutations
259 S 7 12 19 0.604 0.515 View mutations
260 A 5 14 19 0.730 0.645 View mutations
261 L 2 17 19 0.891 0.705 View mutations
262 D 4 15 19 0.835 0.391 View mutations
263 Y 4 15 19 0.748 0.512 View mutations
264 L 6 13 19 0.738 0.556 View mutations
265 H 12 7 19 0.368 0.477 View mutations
266 S 17 2 19 0.119 0.638 View mutations
267 E 5 14 19 0.732 0.328 View mutations
268 K 19 0 19 0.044 0.685 View mutations
269 N 10 9 19 0.425 0.428 View mutations
270 V 1 18 19 0.950 0.720 View mutations
271 V 1 18 19 0.947 0.725 View mutations
272 Y 4 15 19 0.766 0.607 View mutations
273 R 7 12 19 0.661 0.590 View mutations
274 D 0 19 19 1.000 0.799 View mutations
275 L 9 10 19 0.517 0.517 View mutations