P31749 (AKT1)

Overview
Predicted structure (AF):
AF-P31749-F1-model_v4
Uniprot entry:
P31749
Gene:
AKT1
Protein length:
480 residues
Mutations found:
9119
Benign based on D2Deep prediction:
5131 out of 9119 mutations
Pathogenic based on D2Deep prediction:
3988 out of 9119 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 9119 mutations across 480 unique positions. There are 5131 benign and 3988 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
176 Y 8 11 19 0.551 0.507 View mutations
177 A 0 19 19 1.000 0.789 View mutations
178 M 3 16 19 0.842 0.554 View mutations
179 K 0 19 19 0.998 0.743 View mutations
180 I 1 18 19 0.948 0.671 View mutations
181 L 4 15 19 0.758 0.593 View mutations
182 K 4 15 19 0.842 0.533 View mutations
183 K 0 19 19 0.998 0.665 View mutations
184 E 8 11 19 0.499 0.513 View mutations
185 V 17 2 19 0.095 0.426 View mutations
186 I 16 3 19 0.157 0.462 View mutations
187 V 7 12 19 0.607 0.524 View mutations
188 A 17 2 19 0.083 0.407 View mutations
189 K 4 15 19 0.731 0.445 View mutations
190 D 18 1 19 0.159 0.439 View mutations
191 E 0 19 19 0.998 0.443 View mutations
192 V 13 6 19 0.376 0.426 View mutations
193 A 14 5 19 0.280 0.444 View mutations
194 H 0 19 19 0.994 0.499 View mutations
195 T 6 13 19 0.610 0.439 View mutations
196 L 19 0 19 0.013 0.395 View mutations
197 T 10 9 19 0.431 0.426 View mutations
198 E 0 19 19 1.000 0.556 View mutations
199 N 18 1 19 0.064 0.508 View mutations
200 R 6 13 19 0.697 0.440 View mutations