P31751 (AKT2)

Overview
Predicted structure (AF):
AF-P31751-F1-model_v4
Uniprot entry:
P31751
Gene:
AKT2
Protein length:
481 residues
Mutations found:
9138
Benign based on D2Deep prediction:
5179 out of 9138 mutations
Pathogenic based on D2Deep prediction:
3959 out of 9138 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9138 mutations across 481 unique positions. There are 5179 benign and 3959 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
251 R 3 16 19 0.759 0.658 View mutations
252 A 4 15 19 0.801 0.617 View mutations
253 R 2 17 19 0.926 0.657 View mutations
254 F 4 15 19 0.751 0.726 View mutations
255 Y 2 17 19 0.817 0.895 View mutations
256 G 0 19 19 0.998 0.680 View mutations
257 A 0 19 19 0.977 0.780 View mutations
258 E 0 19 19 1.000 0.894 View mutations
259 I 3 16 19 0.862 0.688 View mutations
260 V 18 1 19 0.061 0.439 View mutations
261 S 5 14 19 0.644 0.530 View mutations
262 A 0 19 19 1.000 0.773 View mutations
263 L 2 17 19 0.887 0.718 View mutations
264 E 3 16 19 0.822 0.400 View mutations
265 Y 10 9 19 0.428 0.500 View mutations
266 L 7 12 19 0.599 0.533 View mutations
267 H 0 19 19 0.954 0.659 View mutations
268 S 14 5 19 0.327 0.463 View mutations
269 R 14 5 19 0.306 0.481 View mutations
270 D 7 12 19 0.672 0.520 View mutations
271 V 5 14 19 0.779 0.640 View mutations
272 V 8 11 19 0.515 0.547 View mutations
273 Y 2 17 19 0.843 0.632 View mutations
274 R 0 19 19 1.000 0.889 View mutations
275 D 6 13 19 0.709 0.638 View mutations