P35222 (CTNNB1)

Overview
Predicted structure (AF):
AF-P35222-F1-model_v4
Uniprot entry:
P35222
Gene:
CTNNB1
Protein length:
781 residues
Mutations found:
14838
Benign based on D2Deep prediction:
8232 out of 14838 mutations
Pathogenic based on D2Deep prediction:
6606 out of 14838 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 14838 mutations across 781 unique positions. There are 8232 benign and 6606 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
251 V 1 18 19 0.945 0.680 View mutations
252 L 1 18 19 0.912 0.657 View mutations
253 F 0 19 19 0.990 0.799 View mutations
254 Y 2 17 19 0.900 0.715 View mutations
255 A 0 19 19 0.959 0.757 View mutations
256 I 0 19 19 0.994 0.786 View mutations
257 T 0 19 19 1.000 0.856 View mutations
258 T 0 19 19 1.000 0.905 View mutations
259 L 1 18 19 0.932 0.853 View mutations
260 H 1 18 19 0.951 0.873 View mutations
261 N 0 19 19 1.000 0.920 View mutations
262 L 0 19 19 1.000 0.909 View mutations
263 L 0 19 19 1.000 0.921 View mutations
264 L 0 19 19 0.983 0.924 View mutations
265 H 7 12 19 0.597 0.598 View mutations
266 Q 9 10 19 0.551 0.517 View mutations
267 E 2 17 19 0.894 0.787 View mutations
268 G 2 17 19 0.885 0.757 View mutations
269 A 1 18 19 0.933 0.798 View mutations
270 K 0 19 19 1.000 0.838 View mutations
271 M 3 16 19 0.850 0.643 View mutations
272 A 7 12 19 0.602 0.575 View mutations
273 V 2 17 19 0.886 0.786 View mutations
274 R 0 19 19 1.000 0.883 View mutations
275 L 16 3 19 0.207 0.311 View mutations