P35222 (CTNNB1)

Overview
Predicted structure (AF):
AF-P35222-F1-model_v4
Uniprot entry:
P35222
Gene:
CTNNB1
Protein length:
781 residues
Mutations found:
14838
Benign based on D2Deep prediction:
8232 out of 14838 mutations
Pathogenic based on D2Deep prediction:
6606 out of 14838 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 14838 mutations across 781 unique positions. There are 8232 benign and 6606 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
126 A 3 16 19 0.768 0.541 View mutations
127 E 0 19 19 0.992 0.546 View mutations
128 P 0 19 19 0.997 0.624 View mutations
129 S 4 15 19 0.690 0.542 View mutations
130 Q 0 19 19 0.996 0.522 View mutations
131 M 2 17 19 0.906 0.506 View mutations
132 L 4 15 19 0.766 0.538 View mutations
133 K 7 12 19 0.611 0.511 View mutations
134 H 5 14 19 0.690 0.457 View mutations
135 A 6 13 19 0.720 0.540 View mutations
136 V 9 10 19 0.431 0.504 View mutations
137 V 2 17 19 0.828 0.562 View mutations
138 N 3 16 19 0.802 0.598 View mutations
139 L 4 15 19 0.781 0.635 View mutations
140 I 7 12 19 0.685 0.565 View mutations
141 N 6 13 19 0.612 0.612 View mutations
142 Y 19 0 19 0.001 0.166 View mutations
143 Q 19 0 19 0.001 0.183 View mutations
144 D 8 11 19 0.550 0.555 View mutations
145 D 18 1 19 0.124 0.174 View mutations
146 A 19 0 19 0.002 0.212 View mutations
147 E 1 18 19 0.898 0.788 View mutations
148 L 18 1 19 0.077 0.190 View mutations
149 A 13 6 19 0.328 0.370 View mutations
150 T 19 0 19 0.001 0.223 View mutations