P40337 (VHL)

Overview
Predicted structure (AF):
AF-P40337-F1-model_v4
Uniprot entry:
P40337
Gene:
VHL
Protein length:
213 residues
Mutations found:
4046
Benign based on D2Deep prediction:
2780 out of 4046 mutations
Pathogenic based on D2Deep prediction:
1266 out of 4046 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4046 mutations across 213 unique positions. There are 2780 benign and 1266 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
101 L 19 0 19 0.005 0.264 View mutations
102 P 19 0 19 0.044 0.438 View mutations
103 P 11 8 19 0.409 0.457 View mutations
104 G 2 17 19 0.809 0.725 View mutations
105 T 3 16 19 0.790 0.615 View mutations
106 G 0 19 19 0.986 0.749 View mutations
107 R 18 1 19 0.143 0.273 View mutations
108 R 18 1 19 0.107 0.436 View mutations
109 I 16 3 19 0.237 0.319 View mutations
110 H 19 0 19 0.000 0.382 View mutations
111 S 9 10 19 0.528 0.519 View mutations
112 Y 14 5 19 0.324 0.379 View mutations
113 R 19 0 19 0.015 0.311 View mutations
114 G 19 0 19 0.101 0.247 View mutations
115 H 19 0 19 0.273 0.205 View mutations
116 L 19 0 19 0.026 0.288 View mutations
117 W 0 19 19 0.992 0.684 View mutations
118 L 12 7 19 0.420 0.434 View mutations
119 F 1 18 19 0.951 0.797 View mutations
120 R 2 17 19 0.871 0.619 View mutations
121 D 0 19 19 0.997 0.680 View mutations
122 A 7 12 19 0.621 0.527 View mutations
123 G 1 18 19 0.927 0.612 View mutations
124 T 0 19 19 0.995 0.617 View mutations
125 H 9 10 19 0.494 0.432 View mutations