O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
226 T 17 2 19 0.202 0.388 View mutations
227 Y 18 1 19 0.034 0.363 View mutations
228 L 18 1 19 0.055 0.349 View mutations
229 N 4 15 19 0.773 0.619 View mutations
230 P 1 18 19 0.909 0.822 View mutations
231 W 0 19 19 0.970 0.830 View mutations
232 K 1 18 19 0.873 0.679 View mutations
233 K 0 19 19 0.999 0.775 View mutations
234 I 0 19 19 0.988 0.794 View mutations
235 D 11 8 19 0.399 0.495 View mutations
236 S 19 0 19 0.000 0.474 View mutations
237 A 19 0 19 0.014 0.480 View mutations
238 P 0 19 19 0.982 0.558 View mutations
239 L 1 18 19 0.923 0.682 View mutations
240 A 19 0 19 0.005 0.399 View mutations
241 L 10 9 19 0.440 0.495 View mutations
242 L 4 15 19 0.826 0.647 View mutations
243 H 17 2 19 0.091 0.413 View mutations
244 K 16 3 19 0.185 0.493 View mutations
245 I 9 10 19 0.541 0.430 View mutations
246 L 0 19 19 0.993 0.694 View mutations
247 V 19 0 19 0.016 0.440 View mutations
248 E 17 2 19 0.130 0.488 View mutations
249 N 17 2 19 0.130 0.506 View mutations
250 P 2 17 19 0.768 0.556 View mutations