O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
251 S 18 1 19 0.068 0.446 View mutations
252 A 19 0 19 0.005 0.427 View mutations
253 R 0 19 19 1.000 0.661 View mutations
254 I 18 1 19 0.065 0.457 View mutations
255 T 18 1 19 0.098 0.383 View mutations
256 I 2 17 19 0.885 0.455 View mutations
257 P 18 1 19 0.082 0.449 View mutations
258 D 13 6 19 0.366 0.419 View mutations
259 I 16 3 19 0.205 0.453 View mutations
260 K 18 1 19 0.054 0.406 View mutations
261 K 17 2 19 0.173 0.439 View mutations
262 D 3 16 19 0.857 0.534 View mutations
263 R 19 0 19 0.018 0.361 View mutations
264 W 1 18 19 0.949 0.539 View mutations
265 Y 18 1 19 0.093 0.399 View mutations
266 N 19 0 19 0.003 0.559 View mutations
267 K 5 14 19 0.763 0.382 View mutations
268 P 18 1 19 0.135 0.619 View mutations
269 L 18 1 19 0.081 0.637 View mutations
270 K 6 13 19 0.636 0.372 View mutations
271 K 14 5 19 0.233 0.644 View mutations
272 G 18 1 19 0.153 0.747 View mutations
273 A 19 0 19 0.001 0.785 View mutations
274 K 7 12 19 0.640 0.381 View mutations
275 R 5 14 19 0.699 0.297 View mutations