O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
176 P 2 17 19 0.776 0.684 View mutations
177 E 0 19 19 1.000 0.648 View mutations
178 L 12 7 19 0.396 0.459 View mutations
179 L 4 15 19 0.742 0.579 View mutations
180 K 19 0 19 0.017 0.418 View mutations
181 R 19 0 19 0.001 0.466 View mutations
182 R 19 0 19 0.002 0.434 View mutations
183 E 19 0 19 0.012 0.408 View mutations
184 F 3 16 19 0.752 0.608 View mutations
185 H 19 0 19 0.013 0.382 View mutations
186 A 17 2 19 0.220 0.384 View mutations
187 E 3 16 19 0.822 0.601 View mutations
188 P 2 17 19 0.804 0.686 View mutations
189 V 2 17 19 0.902 0.688 View mutations
190 D 0 19 19 0.990 0.789 View mutations
191 V 3 16 19 0.840 0.610 View mutations
192 W 0 19 19 0.979 0.777 View mutations
193 S 6 13 19 0.637 0.600 View mutations
194 C 0 19 19 0.993 0.843 View mutations
195 G 5 14 19 0.734 0.645 View mutations
196 I 17 2 19 0.099 0.280 View mutations
197 V 15 4 19 0.211 0.340 View mutations
198 L 0 19 19 1.000 0.848 View mutations
199 T 13 6 19 0.313 0.394 View mutations
200 A 0 19 19 0.996 0.830 View mutations