O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
276 P 18 1 19 0.055 0.797 View mutations
277 R 18 1 19 0.061 0.838 View mutations
278 V 19 0 19 0.009 0.883 View mutations
279 T 19 0 19 0.003 0.889 View mutations
280 S 19 0 19 0.004 0.926 View mutations
281 G 17 2 19 0.152 0.798 View mutations
282 G 18 1 19 0.084 0.895 View mutations
283 V 19 0 19 0.002 0.901 View mutations
284 S 19 0 19 0.015 0.994 View mutations
285 E 18 1 19 0.046 0.848 View mutations
286 S 19 0 19 0.000 1.000 View mutations
287 P 19 0 19 0.000 0.933 View mutations
288 S 19 0 19 0.012 0.968 View mutations
289 G 19 0 19 0.004 0.968 View mutations
290 F 17 2 19 0.083 0.850 View mutations
291 S 19 0 19 0.036 0.917 View mutations
292 K 16 3 19 0.138 0.783 View mutations
293 H 19 0 19 0.009 0.892 View mutations
294 I 18 1 19 0.076 0.760 View mutations
295 Q 19 0 19 0.004 0.842 View mutations
296 S 19 0 19 0.001 0.857 View mutations
297 N 17 2 19 0.136 0.752 View mutations
298 L 19 0 19 0.001 0.921 View mutations
299 D 19 0 19 0.017 0.801 View mutations
300 F 19 0 19 0.010 0.839 View mutations