O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
201 M 1 18 19 0.963 0.870 View mutations
202 L 16 3 19 0.171 0.238 View mutations
203 A 19 0 19 0.000 0.053 View mutations
204 G 19 0 19 0.000 0.000 View mutations
205 E 4 15 19 0.795 0.758 View mutations
206 L 0 19 19 1.000 0.932 View mutations
207 P 0 19 19 1.000 0.968 View mutations
208 W 0 19 19 0.998 0.828 View mutations
209 D 2 17 19 0.836 0.794 View mutations
210 Q 19 0 19 0.004 0.299 View mutations
211 P 17 2 19 0.203 0.317 View mutations
212 S 4 15 19 0.793 0.583 View mutations
213 D 7 12 19 0.563 0.530 View mutations
214 S 15 4 19 0.294 0.447 View mutations
215 C 12 7 19 0.348 0.435 View mutations
216 Q 15 4 19 0.232 0.450 View mutations
217 E 16 3 19 0.232 0.293 View mutations
218 Y 2 17 19 0.868 0.692 View mutations
219 S 19 0 19 0.072 0.444 View mutations
220 D 19 0 19 0.002 0.300 View mutations
221 W 15 4 19 0.228 0.377 View mutations
222 K 15 4 19 0.201 0.412 View mutations
223 E 19 0 19 0.000 0.487 View mutations
224 K 19 0 19 0.019 0.467 View mutations
225 K 19 0 19 0.002 0.447 View mutations