O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
301 S 19 0 19 0.001 0.959 View mutations
302 P 19 0 19 0.000 0.835 View mutations
303 V 19 0 19 0.049 0.884 View mutations
304 N 18 1 19 0.053 0.897 View mutations
305 S 19 0 19 0.025 0.985 View mutations
306 A 19 0 19 0.011 0.840 View mutations
307 S 19 0 19 0.007 0.851 View mutations
308 S 19 0 19 0.003 0.808 View mutations
309 E 19 0 19 0.014 0.696 View mutations
310 E 17 2 19 0.086 0.624 View mutations
311 N 19 0 19 0.002 0.724 View mutations
312 V 19 0 19 0.002 0.722 View mutations
313 K 19 0 19 0.003 0.779 View mutations
314 Y 17 2 19 0.093 0.657 View mutations
315 S 19 0 19 0.063 0.658 View mutations
316 S 18 1 19 0.072 0.578 View mutations
317 S 16 3 19 0.159 0.491 View mutations
318 Q 14 5 19 0.303 0.472 View mutations
319 P 5 14 19 0.738 0.433 View mutations
320 E 15 4 19 0.204 0.486 View mutations
321 P 19 0 19 0.034 0.667 View mutations
322 R 19 0 19 0.015 0.791 View mutations
323 T 19 0 19 0.000 0.823 View mutations
324 G 17 2 19 0.150 0.735 View mutations
325 L 19 0 19 0.042 0.735 View mutations