O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
326 S 19 0 19 0.004 0.780 View mutations
327 L 19 0 19 0.002 0.788 View mutations
328 W 19 0 19 0.002 0.718 View mutations
329 D 19 0 19 0.002 0.697 View mutations
330 T 19 0 19 0.002 0.846 View mutations
331 S 17 2 19 0.181 0.778 View mutations
332 P 19 0 19 0.080 0.753 View mutations
333 S 19 0 19 0.001 0.806 View mutations
334 Y 17 2 19 0.087 0.709 View mutations
335 I 19 0 19 0.002 0.680 View mutations
336 D 19 0 19 0.003 0.747 View mutations
337 K 19 0 19 0.004 0.740 View mutations
338 L 19 0 19 0.000 0.724 View mutations
339 V 19 0 19 0.003 0.668 View mutations
340 Q 11 8 19 0.415 0.503 View mutations
341 G 19 0 19 0.024 0.574 View mutations
342 I 16 3 19 0.151 0.454 View mutations
343 S 2 17 19 0.898 0.472 View mutations
344 F 1 18 19 0.922 0.586 View mutations
345 S 1 18 19 0.967 0.630 View mutations
346 Q 19 0 19 0.002 0.407 View mutations
347 P 0 19 19 1.000 0.716 View mutations
348 T 6 13 19 0.642 0.505 View mutations
349 C 15 4 19 0.221 0.402 View mutations
350 P 18 1 19 0.065 0.383 View mutations