O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
351 D 11 8 19 0.402 0.473 View mutations
352 H 15 4 19 0.256 0.449 View mutations
353 M 4 15 19 0.805 0.575 View mutations
354 L 1 18 19 0.896 0.613 View mutations
355 L 11 8 19 0.424 0.475 View mutations
356 N 19 0 19 0.025 0.370 View mutations
357 S 1 18 19 0.942 0.624 View mutations
358 Q 1 18 19 0.892 0.560 View mutations
359 L 6 13 19 0.652 0.522 View mutations
360 L 19 0 19 0.003 0.455 View mutations
361 G 19 0 19 0.006 0.471 View mutations
362 T 2 17 19 0.839 0.533 View mutations
363 P 0 19 19 0.963 0.644 View mutations
364 G 1 18 19 0.913 0.633 View mutations
365 S 18 1 19 0.057 0.488 View mutations
366 S 13 6 19 0.284 0.410 View mutations
367 Q 16 3 19 0.155 0.413 View mutations
368 N 6 13 19 0.671 0.514 View mutations
369 P 18 1 19 0.074 0.402 View mutations
370 W 18 1 19 0.078 0.368 View mutations
371 Q 5 14 19 0.689 0.631 View mutations
372 R 19 0 19 0.058 0.272 View mutations
373 L 1 18 19 0.926 0.679 View mutations
374 V 7 12 19 0.636 0.562 View mutations
375 K 6 13 19 0.722 0.588 View mutations