O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
126 I 13 6 19 0.430 0.458 View mutations
127 T 0 19 19 0.961 0.653 View mutations
128 H 0 19 19 1.000 0.679 View mutations
129 R 0 19 19 0.967 0.721 View mutations
130 D 0 19 19 1.000 0.795 View mutations
131 I 1 18 19 0.947 0.675 View mutations
132 K 0 19 19 1.000 0.747 View mutations
133 P 0 19 19 1.000 0.685 View mutations
134 E 0 19 19 1.000 0.691 View mutations
135 N 9 10 19 0.587 0.511 View mutations
136 L 3 16 19 0.823 0.623 View mutations
137 L 0 19 19 0.993 0.712 View mutations
138 L 2 17 19 0.822 0.640 View mutations
139 D 9 10 19 0.535 0.502 View mutations
140 E 12 7 19 0.357 0.428 View mutations
141 R 19 0 19 0.009 0.432 View mutations
142 D 19 0 19 0.007 0.463 View mutations
143 N 19 0 19 0.000 0.357 View mutations
144 L 8 11 19 0.543 0.519 View mutations
145 K 11 8 19 0.411 0.485 View mutations
146 I 12 7 19 0.399 0.466 View mutations
147 S 5 14 19 0.749 0.584 View mutations
148 D 19 0 19 0.003 0.270 View mutations
149 F 16 3 19 0.151 0.331 View mutations
150 G 18 1 19 0.049 0.207 View mutations