O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
151 L 15 4 19 0.222 0.383 View mutations
152 A 1 18 19 0.963 0.718 View mutations
153 T 8 11 19 0.529 0.547 View mutations
154 V 18 1 19 0.065 0.342 View mutations
155 F 3 16 19 0.841 0.599 View mutations
156 R 15 4 19 0.206 0.468 View mutations
157 Y 18 1 19 0.048 0.445 View mutations
158 N 16 3 19 0.218 0.380 View mutations
159 N 18 1 19 0.054 0.347 View mutations
160 R 12 7 19 0.399 0.487 View mutations
161 E 3 16 19 0.769 0.565 View mutations
162 R 1 18 19 0.962 0.574 View mutations
163 L 19 0 19 0.012 0.499 View mutations
164 L 10 9 19 0.508 0.494 View mutations
165 N 19 0 19 0.001 0.493 View mutations
166 K 2 17 19 0.859 0.561 View mutations
167 M 19 0 19 0.000 0.462 View mutations
168 C 10 9 19 0.468 0.488 View mutations
169 G 14 5 19 0.251 0.383 View mutations
170 T 11 8 19 0.403 0.457 View mutations
171 L 7 12 19 0.603 0.556 View mutations
172 P 18 1 19 0.082 0.254 View mutations
173 Y 16 3 19 0.206 0.262 View mutations
174 V 17 2 19 0.064 0.294 View mutations
175 A 0 19 19 0.974 0.778 View mutations