P06748 (NPM1)

Overview
Predicted structure (AF):
AF-P06748-F1-model_v4
Uniprot entry:
P06748
Gene:
NPM1
Protein length:
294 residues
Mutations found:
5585
Benign based on D2Deep prediction:
4154 out of 5585 mutations
Pathogenic based on D2Deep prediction:
1431 out of 5585 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 5585 mutations across 294 unique positions. There are 4154 benign and 1431 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 A 2 17 19 0.873 0.816 View mutations
52 G 2 17 19 0.841 0.853 View mutations
53 A 2 17 19 0.908 0.823 View mutations
54 K 19 0 19 0.035 0.257 View mutations
55 D 19 0 19 0.000 0.121 View mutations
56 E 14 5 19 0.312 0.338 View mutations
57 L 3 16 19 0.830 0.722 View mutations
58 H 18 1 19 0.071 0.274 View mutations
59 I 12 7 19 0.371 0.416 View mutations
60 V 9 10 19 0.620 0.518 View mutations
61 E 1 18 19 0.942 0.784 View mutations
62 A 0 19 19 0.996 0.780 View mutations
63 E 3 16 19 0.815 0.784 View mutations
64 A 17 2 19 0.197 0.188 View mutations
65 M 16 3 19 0.155 0.261 View mutations
66 N 17 2 19 0.214 0.279 View mutations
67 Y 11 8 19 0.500 0.434 View mutations
68 E 13 6 19 0.269 0.380 View mutations
69 G 19 0 19 0.002 0.105 View mutations
70 S 19 0 19 0.008 0.203 View mutations
71 P 8 11 19 0.516 0.559 View mutations
72 I 14 5 19 0.266 0.298 View mutations
73 K 1 18 19 0.922 0.861 View mutations
74 V 4 15 19 0.750 0.756 View mutations
75 T 17 2 19 0.165 0.218 View mutations