P06748 (NPM1)

Overview
Predicted structure (AF):
AF-P06748-F1-model_v4
Uniprot entry:
P06748
Gene:
NPM1
Protein length:
294 residues
Mutations found:
5585
Benign based on D2Deep prediction:
4154 out of 5585 mutations
Pathogenic based on D2Deep prediction:
1431 out of 5585 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 5585 mutations across 294 unique positions. There are 4154 benign and 1431 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
26 D 18 1 19 0.137 0.403 View mutations
27 K 19 0 19 0.014 0.378 View mutations
28 D 19 0 19 0.010 0.405 View mutations
29 Y 17 2 19 0.185 0.372 View mutations
30 H 18 1 19 0.045 0.473 View mutations
31 F 19 0 19 0.073 0.242 View mutations
32 K 19 0 19 0.012 0.333 View mutations
33 V 7 12 19 0.584 0.581 View mutations
34 D 19 0 19 0.004 0.302 View mutations
35 N 14 5 19 0.256 0.406 View mutations
36 D 19 0 19 0.000 0.302 View mutations
37 E 19 0 19 0.000 0.234 View mutations
38 N 12 7 19 0.420 0.418 View mutations
39 E 9 10 19 0.449 0.515 View mutations
40 H 19 0 19 0.028 0.199 View mutations
41 Q 5 14 19 0.713 0.632 View mutations
42 L 19 0 19 0.004 0.229 View mutations
43 S 19 0 19 0.000 0.282 View mutations
44 L 7 12 19 0.608 0.560 View mutations
45 R 5 14 19 0.727 0.593 View mutations
46 T 14 5 19 0.227 0.435 View mutations
47 V 8 11 19 0.446 0.543 View mutations
48 S 17 2 19 0.122 0.290 View mutations
49 L 7 12 19 0.634 0.596 View mutations
50 G 0 19 19 0.991 0.910 View mutations