P06748 (NPM1)

Overview
Predicted structure (AF):
AF-P06748-F1-model_v4
Uniprot entry:
P06748
Gene:
NPM1
Protein length:
294 residues
Mutations found:
5585
Benign based on D2Deep prediction:
4154 out of 5585 mutations
Pathogenic based on D2Deep prediction:
1431 out of 5585 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5585 mutations across 294 unique positions. There are 4154 benign and 1431 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
201 A 19 0 19 0.013 0.652 View mutations
202 K 19 0 19 0.001 0.765 View mutations
203 N 19 0 19 0.000 0.770 View mutations
204 A 19 0 19 0.000 0.661 View mutations
205 Q 19 0 19 0.014 0.753 View mutations
206 K 19 0 19 0.103 0.757 View mutations
207 S 17 2 19 0.124 0.645 View mutations
208 N 18 1 19 0.045 0.686 View mutations
209 Q 19 0 19 0.016 0.685 View mutations
210 N 19 0 19 0.001 0.501 View mutations
211 G 18 1 19 0.074 0.449 View mutations
212 K 0 19 19 0.984 0.280 View mutations
213 D 16 3 19 0.337 0.468 View mutations
214 S 19 0 19 0.079 0.605 View mutations
215 K 13 6 19 0.405 0.550 View mutations
216 P 14 5 19 0.322 0.559 View mutations
217 S 19 0 19 0.019 0.754 View mutations
218 S 16 3 19 0.238 0.702 View mutations
219 T 17 2 19 0.177 0.631 View mutations
220 P 19 0 19 0.027 0.648 View mutations
221 R 19 0 19 0.002 0.758 View mutations
222 S 19 0 19 0.009 0.649 View mutations
223 K 19 0 19 0.000 0.733 View mutations
224 G 18 1 19 0.045 0.664 View mutations
225 Q 19 0 19 0.001 0.740 View mutations