P06748 (NPM1)

Overview
Predicted structure (AF):
AF-P06748-F1-model_v4
Uniprot entry:
P06748
Gene:
NPM1
Protein length:
294 residues
Mutations found:
5585
Benign based on D2Deep prediction:
4154 out of 5585 mutations
Pathogenic based on D2Deep prediction:
1431 out of 5585 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 5585 mutations across 294 unique positions. There are 4154 benign and 1431 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
76 L 3 16 19 0.818 0.810 View mutations
77 A 15 4 19 0.284 0.211 View mutations
78 T 3 16 19 0.863 0.748 View mutations
79 L 2 17 19 0.839 0.872 View mutations
80 K 1 18 19 0.952 0.801 View mutations
81 M 2 17 19 0.870 0.814 View mutations
82 S 0 19 19 0.977 0.971 View mutations
83 V 5 14 19 0.747 0.737 View mutations
84 Q 19 0 19 0.033 0.121 View mutations
85 P 10 9 19 0.470 0.477 View mutations
86 T 19 0 19 0.000 0.127 View mutations
87 V 5 14 19 0.748 0.681 View mutations
88 S 11 8 19 0.352 0.447 View mutations
89 L 19 0 19 0.001 0.155 View mutations
90 G 19 0 19 0.000 0.172 View mutations
91 G 17 2 19 0.071 0.237 View mutations
92 F 19 0 19 0.000 0.113 View mutations
93 E 10 9 19 0.487 0.482 View mutations
94 I 19 0 19 0.001 0.181 View mutations
95 T 7 12 19 0.585 0.577 View mutations
96 P 12 7 19 0.444 0.429 View mutations
97 P 19 0 19 0.084 0.293 View mutations
98 V 19 0 19 0.015 0.393 View mutations
99 V 15 4 19 0.217 0.458 View mutations
100 L 4 15 19 0.719 0.572 View mutations