P06748 (NPM1)

Overview
Predicted structure (AF):
AF-P06748-F1-model_v4
Uniprot entry:
P06748
Gene:
NPM1
Protein length:
294 residues
Mutations found:
5585
Benign based on D2Deep prediction:
4154 out of 5585 mutations
Pathogenic based on D2Deep prediction:
1431 out of 5585 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 5585 mutations across 294 unique positions. There are 4154 benign and 1431 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
101 R 19 0 19 0.000 0.376 View mutations
102 L 19 0 19 0.056 0.335 View mutations
103 K 16 3 19 0.168 0.436 View mutations
104 C 3 16 19 0.835 0.589 View mutations
105 G 1 18 19 0.945 0.714 View mutations
106 S 19 0 19 0.021 0.264 View mutations
107 G 19 0 19 0.017 0.307 View mutations
108 P 10 9 19 0.473 0.490 View mutations
109 V 19 0 19 0.002 0.225 View mutations
110 H 19 0 19 0.001 0.326 View mutations
111 I 14 5 19 0.257 0.412 View mutations
112 S 14 5 19 0.256 0.372 View mutations
113 G 19 0 19 0.000 0.201 View mutations
114 Q 17 2 19 0.105 0.330 View mutations
115 H 16 3 19 0.219 0.360 View mutations
116 L 16 3 19 0.175 0.350 View mutations
117 V 9 10 19 0.532 0.509 View mutations
118 A 19 0 19 0.006 0.403 View mutations
119 V 18 1 19 0.077 0.433 View mutations
120 E 19 0 19 0.001 0.433 View mutations
121 E 2 17 19 0.873 0.476 View mutations
122 D 19 0 19 0.005 0.386 View mutations
123 A 13 6 19 0.294 0.465 View mutations
124 E 9 10 19 0.537 0.434 View mutations
125 S 5 14 19 0.691 0.397 View mutations