P06748 (NPM1)

Overview
Predicted structure (AF):
AF-P06748-F1-model_v4
Uniprot entry:
P06748
Gene:
NPM1
Protein length:
294 residues
Mutations found:
5585
Benign based on D2Deep prediction:
4154 out of 5585 mutations
Pathogenic based on D2Deep prediction:
1431 out of 5585 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 5585 mutations across 294 unique positions. There are 4154 benign and 1431 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
126 E 19 0 19 0.058 0.549 View mutations
127 D 6 13 19 0.710 0.410 View mutations
128 E 1 18 19 0.941 0.359 View mutations
129 E 19 0 19 0.020 0.557 View mutations
130 E 3 16 19 0.803 0.374 View mutations
131 E 4 15 19 0.643 0.384 View mutations
132 D 6 13 19 0.675 0.424 View mutations
133 V 19 0 19 0.018 0.456 View mutations
134 K 18 1 19 0.095 0.507 View mutations
135 L 19 0 19 0.004 0.368 View mutations
136 L 18 1 19 0.085 0.450 View mutations
137 S 19 0 19 0.067 0.491 View mutations
138 I 18 1 19 0.060 0.478 View mutations
139 S 18 1 19 0.060 0.435 View mutations
140 G 16 3 19 0.193 0.498 View mutations
141 K 18 1 19 0.051 0.382 View mutations
142 R 19 0 19 0.001 0.565 View mutations
143 S 19 0 19 0.000 0.382 View mutations
144 A 17 2 19 0.113 0.477 View mutations
145 P 19 0 19 0.000 0.496 View mutations
146 G 19 0 19 0.000 0.492 View mutations
147 G 17 2 19 0.130 0.428 View mutations
148 G 19 0 19 0.000 0.483 View mutations
149 S 19 0 19 0.001 0.458 View mutations
150 K 19 0 19 0.000 0.424 View mutations