P06748 (NPM1)

Overview
Predicted structure (AF):
AF-P06748-F1-model_v4
Uniprot entry:
P06748
Gene:
NPM1
Protein length:
294 residues
Mutations found:
5585
Benign based on D2Deep prediction:
4154 out of 5585 mutations
Pathogenic based on D2Deep prediction:
1431 out of 5585 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 5585 mutations across 294 unique positions. There are 4154 benign and 1431 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
151 V 19 0 19 0.008 0.376 View mutations
152 P 1 18 19 0.930 0.598 View mutations
153 Q 19 0 19 0.044 0.413 View mutations
154 K 18 1 19 0.081 0.378 View mutations
155 K 5 14 19 0.695 0.452 View mutations
156 V 19 0 19 0.002 0.459 View mutations
157 K 19 0 19 0.004 0.412 View mutations
158 L 17 2 19 0.195 0.456 View mutations
159 A 19 0 19 0.001 0.521 View mutations
160 A 19 0 19 0.003 0.623 View mutations
161 D 19 0 19 0.009 0.701 View mutations
162 E 13 6 19 0.396 0.580 View mutations
163 D 18 1 19 0.059 0.824 View mutations
164 D 19 0 19 0.031 0.939 View mutations
165 D 19 0 19 0.015 0.959 View mutations
166 D 19 0 19 0.002 0.950 View mutations
167 D 19 0 19 0.000 0.961 View mutations
168 D 19 0 19 0.003 0.999 View mutations
169 E 19 0 19 0.001 1.000 View mutations
170 E 19 0 19 0.000 0.954 View mutations
171 D 19 0 19 0.025 0.963 View mutations
172 D 19 0 19 0.001 0.981 View mutations
173 D 19 0 19 0.001 0.957 View mutations
174 E 19 0 19 0.002 0.951 View mutations
175 D 19 0 19 0.000 0.975 View mutations